Biochem/physiol Actions

Reversible: no

Target IC₅₀: 2.24 nM against cathepsin B

Primary Targetcathepsin B

Product does not compete with ATP.

Cell permeable: yes

General description

A cell-permeable analog of CA-074 (Cat. No. 205530) that acts as an irreversible inhibitor of intracellular cathepsin B.

A cell-permeable analog of CA-074 (Cat. No. 205530) that acts as an irreversible inhibitor of intracellular cathepsin B. Reported to inhibit bone resorption in rodent models and shown to inhibit B16 melanoma cell invasion in vitro.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Sever, N., et al. 2002. Biol. Chem.383, 839.Authier, F., et al. 1999. J. Biol. Chem.274, 33723.Hill, P.A., et al. 1994. J. Cell Biochem. 56, 118.Buttle, D.J., et al. 1992. Arch. Biochem. Biophys. 299, 377.

Packaging

1 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)